An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of any [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase (EC 2.7.11.31).
ChEBI ID: 78622
| Member | Definition | Class |
|---|---|---|
| dorsomorphin | A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling. | dorsomorphin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 55 (15.45) | 29.6817 |
| 2010's | 259 (72.75) | 24.3611 |
| 2020's | 42 (11.80) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.28%) | 5.53% |
| Reviews | 8 (2.20%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 354 (97.52%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 18.8337 | 4 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 37.2212 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 10.4353 | 1 | 3 |
| polyprotein | Zika virus | Potency | 37.2212 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 10.4353 | 1 | 2 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 707.9460 | 1 | 1 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 0.1253 | 2 | 2 |